Sunday, August 25, 2019

Combination of Natural Supplements as Adjunct Cancer Therapy

A question I'm often asked is "which supplements to choose" from this list of 72 natural anticancer substances. It really depends on the type and stage of cancer. Some cancers grow very slowly, like prostate cancer. The 5-year survival for this cancer in stage 1 or 2 is 99%. In such cases, you probably shouldn't do anything outside standard medical treatment, unless you're eating a pro-inflammatory diet.  However, if the prognosis is considerably less favorable it makes sense to combine standard therapy with a diet designed to slow down cancer, exercise, supplements and/or alternative therapies. The emphasis here is on trying to enhance standard care, not delay, or substitute any part of the conventional medical protocol because, in many cases, the decision to opt-out of (additional) conventional treatments seems to worsen outcome.

But there's no doubt it's possible to significantly improve outcome with various natural products, as this randomized study with aloe arborescens in patients with metastatic cancer, and many other studies have shown. Some supplements can be extremely helpful in reversing cancer. Unfortunately, it seems that very often there's little or no follow-through when a readily available natural product shows great potential in cancer treatment.

That said, I've made a shorter list of natural anticancer supplements. The main criteria used in this selection are safety, action against many types of cancer, different mechanisms of anticancer activity, possible synergies and scientific evidence of efficacy.
  1. Artemisinin: 200 - 500 mg/day in one dose or two (divided doses, one every 12 h.) and on an empty stomach or 2 hours after last meal, and with cod liver oil for better absorption. Intermittent dosing (4-5 days on/2-3 days off) 6 up to 24 months. Alternative: Artesunate ** Cost: ≈ $3,3/day at high dose. 
  2.  Honokiol: 1-3 gr/day in 2 or 3 divided doses. Honokiol+Magnolol>95% Cost: ≈ $1,2/day for 2gr/day or HonoPure ≈ $6,8/day for 2gr/day 
  3. Curcumin4-8gr/day, take with meals. 4-week cycles (4 weeks On/1 or 2 weeks Off). Up to 24 months. Cost: ≈ $1,15/day for 3gr/day.
  4. → Epigallocatechin gallate (EGCG): 800mg/day. 400mg twice daily. For best absorption take with filtered water(not mineral water) and with Omega 3 fish oil supplement(take the omega 3 first, then the EGCg), as this can also increase bioavailability and may enhance its efficacy. Cost: ≈ $0,19/day 
  5. → Berberine: 500 - 1500 mg/day 4 days per week during 6-8 week cycles, take with meals. Cost: ≈ $1,13/day for 1000mg/day
  6.       Triphala
  7. → Ursolic acid: 0,5- 1gr/day divided in 2 doses (breakfast,dinner). Take with some coconut oil for better absorption. 4 week cycles (4 weeks On/1 or 2 weeks Off). Cost: ≈ $1,7/day for 0,5/gr/day
  8. Allicin: therapeutic amounts of stable Allicin in the bloodstream can be obtained by taking a supplement called Allimed.
  9. IP6: 500mg - 18 g/day
  10. Panax Ginseng: 800-2000mg/day (in divided doses, morning, afternoon). Cost: ≈ $0,25/day for 1500mg/day
  11. Citric Acid0.05 to 0.1g/kg/day with water and with meals (in  2 or 3 divided doses). Cost: ≈ $0,11/day for 5gr/day. 
  12. Turkey Tail: Trametes or Coriolus Versicolor, 4 g twice daily. Cost: ≈ $3/day
  13. C-phycocyanin: 0.8-1.6 gr/day in 2 or 3 divided doses or 4-8 g Spirulina/day (Spirulina is about 20% C-phycocyanin by weight.) Cost: ≈ $1/day. 
  14. Jiaogulan:  5-20mg/kg/day (1 kg =2.20462 lb) in 4 week cycles (4 weeks On/1 or 2 weeks Off). Take between meals. Rich source of dammarane-type saponins Cost: ≈ $0,73/day for 750mg/day
  15. D-limonene: 0.5-3gr/day, in divided doses.
  16. Black cumin seed oil: 3-4 x 500mg caps./day, or if you can stand the taste, 1/2 to 1 teaspoon of the oil (with or before breakfast). You can mix the oil in some orange juice. 
  17. Emodin (rhubarb extract)
  18. Salvia militiorrhiza: contains Tanshinone IIA. 1 tablet twice daily with a meal. Cost: ≈ $0,23/day
  19. Luteolin: 100-200mg/day, in divided doses with meals. Taking Luteolin with olive leaf extract may increase absorption.
  20. Pyrroloquinoline Quinone(PQQ): 20-40mg/day, after meals.  Cost: ≈ $1,3/day at high dose. Consider taking with coQ10 and/or oil of oregano for synergy
  21. Holy basil: contains Oleanolic Acid. 2-3 caps/day (Himalaya, Holy Basil, Cost: ≈ $0,5/day)
  22. Piperlongumine:  therapeutically effective amount could start as low as less than 0.1mg/kg/day and max. dose 2.4mg/kg/day. Cost  
  23. Iodine: at least 1000 mcg/day, take with selenium(sodium selenite).
  24. Fucoidan: 3-6gr/day, in 3 or 4 divided doses.
  25. Ashwagandha: contains Withaferin A. Root and leaf extract. 1200mg-6000mg/day in 2 divided doses (afternoon and evening).  Cost: ≈ $0,43/day for 1500mg/day
  26. Modified Citrus Pectin
  27. Melatonin: 3-15mg/day at night.  Cost: ≈ $0,3/day for 9mg/day.
  28. Bovine Tracheal Cartilage: In 1972 Dr.Prudden started a clinical study treating terminally ill cancer patients with bovine tracheal cartilage. He treated 31 patients and all but one far exceeded life expectancy. Bovine tracheal cartilage is very safe to use and has virtually no side-effects. 9 gram/day (in 3x 3gr doses) followed by a 3gr/maintenance dose. Cost: ≈ $3,7/day.
 Cautions regarding combining supplements and medication

Read This First

If you take medications double check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc.

💊 To combine various supplements add one at a time, start with the lowest possible dose and gradually increase if no side effect is observed.

To discontinue a supplement taper off by cutting to a half-dose for a week before stopping.

Dosage, but also time is crucial to producing a therapeutic effect.

Synergies

 Artemisinin with Honokiol
 Because of the low bioavailability of Curcumin, I suggest to combine curcumin with natural products that act synergistically:

** On days/cycles with Artemisinin avoid Luteolin, Curcumin, EGCg because these are iron chelators and could reduce the effectiveness of Artemisinin.

🏃 Aerobic activity improves outcomeAt least 20 studies of people with breast, colorectal, prostate, and ovarian cancer have suggested that physically active cancer survivors have a lower risk of cancer recurrence and improved survival compared with those who are inactive.


Partial list of studies:
  1. The Treatment of Human Cancer with Agents Prepared from Bovine Cartilage Prudden John F. Journal of Immunotherapy: December 1985
  2. Dr. Prudden’s 31 Cases: Treating Cancer with Bovine Tracheal Cartilage
  3. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy.
  4. Methods for the treatment of cancer using piperlongumine and piperlongumine analogs
  5. The central role of citrate in the metabolism of cancer cells. "citrate has demonstrated anti-cancer properties when administered in excess, sensitizing cancer cells to chemotherapy."
  6. Turkey Tail and Polysaccharide-K
  7. Red (Panax) ginseng and cancer treatment.
  8. Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review.
  9. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.
  10. Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1Îą inhibition
  11. Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer
  12. Curcumin And Berberine – Offers New Hope In The Treatment Of Breast And Other Cancers?
  13. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
  14. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
  15. Therapeutic Interventions Using Ursolic Acid for Cancer Treatment
  16. Melatonin for the prevention and treatment of cancer
  17. Recent advances in the anti-cancer properties of Nigella sativa, a widely used food additive
  18. Phycocyanin: A Potential Drug for Cancer Treatment
  19. Pyrroloquinoline quinone induces chondrosarcoma cell apoptosis by increasing intracellular reactive oxygen species
  20. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
  21. Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway
  22. Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
  23. D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
  24. A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
  25. Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency
  26. Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report
  27. Effects of supplements on medicines
When you have exhausted all possibilities, remember this: You haven't.