Curcumin

Curcumin is a component of the spice turmeric (Curcumin longa). Many studies have demonstrated the anti-cancer properties of curcumin. Some of its mechanisms of action against cancer are:
  • reduction of ATP production i.e. starve cancer cells
  • anti-angiogenic (inhibition of VEGF secretion, VEGFR2 activation) {review}
  • inhibition of the STAT3 and NF-ΚB signaling pathways
  • downregulation of pyruvate kinase M2 (decreases Warburg effect)
  • downregulation of Her-2 {article}
  • PKC inhibitor {Ref}
  • chemosensitization of tumor cells
  • induction of apoptosis {review|study}
source

In addition, curcumin also enhances several conventional chemotherapy treatments e.g.
  • combined treatment of docetaxel and curcumin
  • curcumin and cisplatin

⚡ Potential synergistic effects

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increases the anti-cancer effect in combination with other natural compounds:
ToxicityA phase 1 human trial with 25 subjects using up to 8000 mg (8 gr) of curcumin (standardized extract) daily for 3 months found no toxicity from curcumin.

Supplements 

Special formulas for higher bioavailability of curcumin: This is a list, not a ranking, of some of the best curcumin supplements on the market. 
      1. BioCurc®: a proprietary curcumin liquid droplet micromicellar (CLDM) formulation
        source
      2. CurcuWin®: A formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives, and natural antioxidants increases bioavailability significantly (▲ 46-fold claimed in one study)
      3. Longvida®: patented Solid Lipid Curcumin Particle (SLCPTM) Technology. Concerning bioactivity "In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected."{study}
      4. CAVACURMIN®: cyclodextrin nanoformulation (CW8 in the study below) to improve the bioactivity of curcumin. Note that plasma concentration is a surrogate marker that influences but doesn’t guarantee positive clinical results, which depend on complex properties of the supplement.
        source
      5. TetraCumin-QRcyclodextrin nanoformulation with tetrahydrocurcumin (THC), a metabolite of curcumin. The same argument in favor of bioavailability applies here. Additional claim: better solubility of THC.                                                    The following study is interesting as it shows clear differences in activities between curcumin and tetrahydrocurcumin: Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses "Curcumin appears to bind to and modulate the activities of a wide variety of targets. THC, however, appears to be a superior antioxidant that lacks both anti-inflammatory and pro-oxidant activities. Curcumin contains a number of functional groups that are involved in target modulation. More in vivo data, especially clinical trials, are needed to determine which is a better molecule." 
      6. Curcumin C3-complex® + Bioperine: the C3 complex doesn’t influence bioactivity but provides a high standardized amount of curcumin and curcuminoids. Piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in humans with no adverse effects.{study}. Curcumin piperine combinations are well studied; also, efficacy is more or less confirmed by clinical trials. Possibly not as effective as products that use above mentioned nanotechnologies and formulations. Products using this type of formulation: Mega Potency Super Curcumin 1000, Curcumin C3 Complex
Last updated on October 26, 2019
Cautiondon't take curcumin if on warfarin (Coumadin) or other anticoagulants, as it will magnify the effect of the drugs. Do not take prior to surgery

Curcumin could reduce the effectiveness of Tamoxifen.

💊 Check drug interactions

It's best not to drink caffeinated beverages within 2 hours of taking curcumin as Curcumin can be deactivated by glucuronidation in the liver.

Turmeric Almond Milk: How To Make This Anti-inflammatory Drink The Right Way



References & Sources

different types of nanotechnologies



  • Curcumin degradation products                  
    source



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