Micronutrient Synergies ⚡

Food Synergy: two or more foods or substances can be greater than the sum of their parts. Here are a few examples:

  1. Garlic + Turmeric anticholesterol effect {study}
  2. Tomato (lycopene) + broccoli (sulforaphane): daily 1.4 cups of raw broccoli and 2.5 cups of fresh tomato, or 1 cup of tomato sauce, or 1/2 cup of tomato paste. {article} prostate health/prevention
  3. Turmeric + garlic + ginger {study}
  4. Honokiol + Magnolol
  5. Honokiol + Modified Citrus Pectin
  6. Selenium + sulforaphane: up to 13 times more effective than either nutrient alone. {article}
  7. Vit C(ascorbic acid) + Vitamin K3 100:1 {study}
  8. Lysine + Ascorbic acid + Green Tea Extract 
  9. EGCG + Quercetin {study|study}
  10. Luteolin + EGCG {study}
    • IP6 + Inositol
    • IP6 + catechins catechin and IP6 amplified VEGF reduction {study}
    • Garcinol + Curcumin: 2 to 10 fold that of the individual agents on pancreatic cancer cells.
    • Grape Seed Extract + Green Tea
    • Green tea + Curcumin {study|study p21|study|study}
    • Curcumin + Boswellia {video}
    • Curcumin + Berberine
    • Curcumin + Ursolic Acid
    • Curcumin + Ascorbic acid {Curcumin antifungal and antioxidant activities are increased 5-10 fold in the presence of ascorbic acid study}
    • Ascorbic acid, Zinc, Selenium, and Quercetin
    • Pomegranate, Broccoli, Turmeric and Green tea.
    • Laetrile, Ascorbic acid and pancreatic enzymes.
    • Vitamin D + Lycopene {study inhibition of prostate and mammary cancer cells study leukemic cells
    • Garlic + Artesunate {study}
    • D-limonene + Berberine {study}
    • Maitake + Ascorbic acid {study}
    • Carnosic acid + Curcumin {study}
    • Curcumin + black seed oil antiviral {study}
    • Curcumin + DHA {study}
    • Curcumin + Ascorbic acid {study} "both natural products may work together by different molecular pathways to achieve their overall cytotoxicity. Unlike chemically synthesized drugs, natural products might be active at lower doses and over longer periods of incubation, which could further support the appearance of additive effects."
    • Vitamin D3 + Sulforophane {study|study|study|study|article}
    • Melatonin + Vitamin D3 {study}
    • Curcumin + Sulforaphane {study|study|study "Data from this study demonstrate thata low-dose ACS combination inhibits cell growth by inducing cell apoptosis, and proposes sustained activation of the ERK1/2signaling pathway as one of the possible mechanisms"}
    • Curcumin + Silymarin {study}
    • Aspirin + Curcumin + Sulforaphane " From our studies, we report a 2–5-fold reduction in doses with ASP (1 mM) and CUR (10 ΞΌM). Similarly, 20–40 ΞΌM of SFN is reported to be active against various cancers, whereas our dose of 5 ΞΌM concentration in combination with ASP and CUR reduced the concentration by 4–8 times (18,21,22). Subsequent studies using apoptosis and colony formation assays confirmed these observations and further strengthen the hypothesis of synergistic effect using combinatorial regimens" {study}
    • EGCg + CapsaicinCatechin-vanilloid synergies with potential clinical applications in cancer.
    • Curcumin + Honokiol + Apigenin: {link|study}
    • Sulforaphane + EGCg: {study}
    • Galangin + Berberine: {study}
    • Maitake + Sulforaphane: "synergistic effect of the combination of sulforaphane and a maitake extract on the gene expression of Phase 2 detoxifying enzymes NQO1 and UGT1A1 suggesting the agents together may be effective at detoxifying the body of excess estrogens"{article}
    • EGCg (green tea) + lemon: "Citrus juices, including fromlimes, grapefruits, lemons and oranges,increased the levels of catechins by more than five times, with an 81 to 98 per cent recovery for EGC, 56 to 75 per cent for EGCG, 86 to 95 per cent for EC and 30 to 55 per cent for ECG. Lemon juice was the most effective at preserving catechins in green tea, the study found."{article}
    • Curcumin + Triptolide:{study}
    • Emodin + Curcumin: {study|study}
    • Resveratrol + Artemisinin: {study}
    • Curcumin + Resveratrol: {study}
    • EGCG + Silibinin: {study}
    • Thymoquinone + Melatonin: {study}
    • Cucurbitacin B + Curcumin: {study}
    • Lipoic acid + hydroxycitrate: "The combination was used to treat mouse syngeneic cancer models: MBT-2 bladder transitional cell carcinoma, B16-F10 melanoma and LL/2 Lewis lung carcinoma. The efficacy of this combination appears similar to conventional chemotherapy (cisplatin or 5-fluorouracil) as it resulted in significant tumor growth retardation and enhanced survival." {study| + capsaicin study
    • Shark liver oil + theobromine {book} anti-angiogenisis, tumor suppression
    • Citrus limonoids + Curcumin: {study}

    Synergetic combinations of Supplements/herbs and prescription and OTC drugs

    • Melatonin + Tamoxifen {study}
    • Aspirin + Curcumin/Turmeric {article}
    • Metformin + Vitamin D3
    • Hydroxycitric acid + Tamoxifen {study}
    • Curcumin + docetaxel: Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin {study| study}
    • Berberine + sorafenib: {study}
    • White & green tea + Sulindac: {study}
    • EGCg + Sulindac/Tamoxifen:{study}
    • GuaranΓ‘ + oxaliplatin: {study}
    • Caffeine + immune checkpoint inhibitors: {study}
    • Honokiol + Adriamycin: {study}
    • Caffeine citrate + cisplatin: {study}
    • Ibuprofen + EGCg: {study}

    Cautions regarding combining supplements and medication. Stop taking supplements 2 weeks prior to surgery, or consult with your surgeon. If you take medications check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc. πŸ’Š To combine various supplements add one at a time, start with the lowest possible dose and gradually increase if no side effect is observed. And of course, consult your doctor.

    References & Sources


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